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Die `!Mutationsanalyse`! wird in der `F33f`_`[Humangenetik`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Humangenetik]`_`f angewandt, um `F33f`_`[Mutationen`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Mutation]`_`f ausfindig zu machen und damit festzustellen, ob ein Patient an einer `F33f`_`[Erbkrankheit`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Erbkrankheit]`_`f leidet oder nicht.

>>Contents

• `F0af`_`[Methoden der Mutationsanalyse`#methoden-der-mutationsanalyse]`_`f

• `F0af`_`[Literatur`#literatur]`_`f

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>>Methoden der Mutationsanalyse

• `F33f`_`[SSCP`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=SSCP]`_`f (Single-Stranded Conformation Polymorphism Analysis)

• DHPLC (Denaturing High Performance Liquid Chromatography, selten auch `*Denaturating`* `F33f`_`[HPLC`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Hochleistungsflüssigkeitschromatographie]`_`f)

• `F33f`_`[DNA-Chip`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=DNA-Chip]`_`f-Technologie

• Two Dimensional Gene Scanning (TDSG)-Technologie

• Conformation Sensitive Gel Electrophoresis (CSGE)-Technologie

>>Literatur

• B. Yu, S. A. O’Toole, R. J. Trent: `*Somatic DNA mutation analysis in targeted therapy of solid tumours.`* In: `*Translational pediatrics.`* Band 4, Nummer 2, April 2015, S. 125–138, `F33f`_`[doi`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Digital_Object_Identifier]`_`f:10.3978/j.issn.2224-4336.2015.04.04, PMID 26835368, PMC 4729091 (freier Volltext).

• M. Gundry, J. Vijg: `*Direct mutation analysis by high-throughput sequencing: from germline to low-abundant, somatic variants.`* In: `*Mutation research.`* Band 729, Nummer 1–2, Januar 2012, S. 1–15, `F33f`_`[doi`:/page/entry.mu`zim=wikipedia_de_all_nopic_2026-01.zim|entry_path=Digital_Object_Identifier]`_`f:10.1016/j.mrfmmm.2011.10.001, PMID 22016070, PMC 3237897 (freier Volltext).

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